Phrixotoxin-2, Kv4.2 and Kv4.3 channel blocker (ab141843)
Key features and details
- Potent, selective and reversible Kv4.2 and Kv4.3 channel blocker
- CAS Number: 221889-63-0
- Purity: > 98%
- Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Phrixotoxin-2, Kv4.2 and Kv4.3 channel blocker -
Description
Potent, selective and reversible Kv4.2 and Kv4.3 channel blocker -
Biological description
Potent, selective Kv4.3 and Kv4.2 potassium channel inhibitor (IC50 values are 71 and 34 nM, respectively). Anticancer activitiy. Active in vivo. -
Purity
> 98% -
CAS Number
221889-63-0 -
Chemical structure
Properties
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Chemical name
YCQKWMWTCDEERKCCEGLVCRLWCKRIINM (Modifications: Met-31= C-terminal amide; Disulfide bridges: 2-16, 9-21 and 15-25) -
Molecular weight
3923.00 -
Molecular formula
C169H259N49O43S8 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
Images
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Functional Studies - Phrixotoxin-2, Kv4.2 and Kv4.3 channel blocker (ab141843)Phrixotoxin-2 inhibits KV4.3 currents expressed in Xenopus oocytes.
Expressed KV4.3 currents were recorded using two electrode voltage clamp with ND 96 in the bath solution. Left: Traces of current response to 100 ms depolarization from a holding potential of -100 mV to -10 mV, applied every 10 sec before, during and after wash of Phrixotoxin-2 (ab141843) at the indicated concentrations. Middle: Mean and S.D. dose response curve for 3 experiments. Right: Mean and S.D. voltage dependence of the percentage inhibition caused by 1 µM Phrixotoxin-2 (n = 3).