PF-562271, ATP-competitive, reversible FAK Inhibitor (ab141360)
Key features and details
- Potent, selective ATP-competitive, reversible FAK Inhibitor
- CAS Number: 717907-75-0
- Purity: > 95%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PF-562271, ATP-competitive, reversible FAK Inhibitor -
Description
Potent, selective ATP-competitive, reversible FAK Inhibitor -
Biological description
Potent, selective ATP-competitive, reversible FAK Inhibitor (IC50 values are 1.5, 13, 30, 47 and 58 nM for FAK, PYK2, CDK2, CDK2 and CDK1 respectively). Downregulates AKT/mTOR and CAS activity. Induces apoptosis. Shows antitumor effects in vivo. Orally active. -
Purity
> 95% -
CAS Number
717907-75-0 -
Chemical structure
Properties
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Chemical name
N-Methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide -
Molecular weight
507.50 -
Molecular formula
C21H20F3N7O3S -
PubChem identifier
11713159 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(c1c(cccn1)CNc2c(cnc(n2)Nc3ccc4c(c3)CC(=O)N4)C(F)(F)F)S(=O)(=O)C -
Source
Synthetic
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Research areas
