PD123319 di(trifluoroacetate), angiotensin AT2 receptor antagonist (ab144564)
Key features and details
- Potent, selective, non-peptide angiotensin AT2 receptor antagonist
- CAS Number: 136676-91-0
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PD123319 di(trifluoroacetate), angiotensin AT2 receptor antagonist -
Description
Potent, selective, non-peptide angiotensin AT2 receptor antagonist -
Biological description
Potent, selective, non-peptide angiotensin AT2 receptor antagonist (IC50 values are 34 and 210 nM for rat adrenal and brain tissue respectively). Reduces angiotensin II-induced oxidative stress. Orally active.
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Purity
> 98% -
CAS Number
136676-91-0 -
Chemical structure
Properties
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Chemical name
(6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) -
Molecular weight
736.66 -
Molecular formula
C31H32N4O3.2CF3CO2H -
PubChem identifier
6604951 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.CN(C)c1ccc(cc1C)Cn2cnc3CN([C@@H](Cc23)C(=O)O)C(=O)C(c4ccccc4)c5ccccc5 -
Source
Synthetic
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Research areas
