PACAP (1-27) (human, ovine, rat), receptor antagonist (ab142326)
Key features and details
- Potent PACAP receptor antagonis. Stimulates adenylate cyclase.
- CAS Number: 127317-03-7
- Purity: > 95%
- Soluble in water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PACAP (1-27) (human, ovine, rat), receptor antagonist -
Description
Potent PACAP receptor antagonis. Stimulates adenylate cyclase. -
Biological description
Potent PACAP receptor antagonist (IC50 = 7.45 nM). Stimulates adenylate cyclase more potently than VIP (ab120180). High binging affinity in lung. Active in vitro and in vivo. -
Purity
> 95% -
CAS Number
127317-03-7 -
Chemical structure
Properties
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Molecular weight
3147.68 -
Molecular formula
C142H224N40O39S -
Sequence
HSDGIFTDSYSRYRKQMAVKKYLAAVL (Modifications: C-terminal amide) -
PubChem identifier
44134520 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC[C@H](C)[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@H](Cc2ccc(cc2)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](Cc3ccc(cc3)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc4ccc(cc4)O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N)NC(=O)CNC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H]( -
Source
Synthetic
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Research areas