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mSin3A peptide (ab4995)

Key features and details

  • Suitable for: Blocking

Description

  • Product name

    mSin3A peptide

  • Animal free

    No

  • Nature

    Synthetic

Preparation and Storage

  • Alternative names

    • AW553200
    • DKFZP434K2235
    • FLJ90319
    • Histone deacetylase complex subunit Sin 3a
    • Histone deacetylase complex subunit Sin3a
    • KIAA0700
    • Kiaa4126
    • mKIAA4126
    • Paired amphipathic helix protein Sin 3a
    • Paired amphipathic helix protein Sin3a
    • Sin 3a
    • SIN3 homolog A
    • SIN3 homolog A transcription regulator
    • SIN3 homolog A transcription regulator (yeast)
    • SIN3 transcription regulator homolog A
    • Sin3a
    • SIN3A protein
    • SIN3A_HUMAN
    • Transcriptional co repressor Sin 3A
    • Transcriptional co repressor Sin3A
    • Transcriptional corepressor Sin3a
    • Transcriptional regulator SIN3A
    see all

  • Function

    Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3A to DNA. Acts as a corepressor for REST.

  • Sequence similarities

    Contains 3 PAH (paired amphipathic helix) domains.

  • Post-translational
    modifications

    SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.

  • Cellular localization

    Nucleus. Nucleus > nucleolus. Recruited to the nucleolus by SAP30L.
  • Information by UniProt

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