LY 2228820, p38 MAPK inhibitor (ab143833)
Key features and details
- A novel and potent inhibitor of p38 MAPK
- CAS Number: 862507-23-1
- Purity: > 98%
Soluble in water to 163.2 mM, in DMSO to 6.52 mM and in Ethanol to 4.89 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
LY 2228820, p38 MAPK inhibitor -
Description
A novel and potent inhibitor of p38 MAPK -
Alternative names
- 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine;methanesulfonic acid
- LY2228820 dimesylate
- Mesylate
see all -
Biological description
LY 2228820 is a novel and potent p38 MAPK inhibitor with potent anti-inflammatory activity. It significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY 2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events. IC50 of 7 nM in a cell-free assay.
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Purity
> 98% -
General notes
Protect from air and light.
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CAS Number
862507-23-1 -
Chemical structure
Properties
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Chemical name
5-[2-(1,1-Dimethylethyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine Dimethanesulfonate
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Molecular weight
612.74 -
Molecular formula
C26H37FN6O6S2 -
PubChem identifier
11570805 -
Storage instructions
Shipped at 4°C. Store at -20°C long term. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in water to 163.2 mM, in DMSO to 6.52 mM and in Ethanol to 4.89 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O -
Source
Synthetic
