Losartan potassium, non-peptide angiotensin II AT1 receptor antagonist (ab120997)
Key features and details
- Selective non-peptide angiotensin II AT1 receptor antagonist
- CAS Number: 124750-99-8
- Purity: > 99%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Losartan potassium, non-peptide angiotensin II AT1 receptor antagonist -
Description
Selective non-peptide angiotensin II AT1 receptor antagonist -
Biological description
Selective non-peptide angiotensin II type 1 (AT1) receptor antagonist (Ki = 10 nM). Blocks classical actions of angiotensin II (ab120183). Displays antihypertensive action and downregulates TFG-β regulation. Active in vivo.
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Purity
> 99% -
CAS Number
124750-99-8 -
Chemical structure
Properties
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Chemical name
2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt -
Molecular weight
461.01 -
Molecular formula
C22H22ClKN6O -
PubChem identifier
11751549 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[K]n4nnnc4c1ccccc1c3ccc(Cn2c(CO)c(Cl)nc2CCCC)cc3 -
Source
Synthetic
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Research areas
