KN-93, CaM kinase II inhibitor (ab145638)
Key features and details
- Potent, cell-permeable CaM kinase II inhibitor. Potent voltage gated K+ channel blocker.
- CAS Number: 139298-40-1
- Purity: > 98%
- Soluble in DMSO to 100 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
KN-93, CaM kinase II inhibitor -
Description
Potent, cell-permeable CaM kinase II inhibitor. Potent voltage gated K+ channel blocker. -
Biological description
Potent, cell-permeable CaM kinase II inhibitor (IC50 = 370 nM). Potent voltage gated K+ channel blocker (IC50 = 307 nM, KV1.5). Analog of water soluble KN-93 (ab120980). Suppresses early afterdepolarization. Induces ROS generation and apoptosis. Shows central effects in vivo. -
Purity
> 98% -
CAS Number
139298-40-1 -
Chemical structure
Properties
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Chemical name
N-[2-[[[(E)-3-(4-Chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide -
Molecular weight
501.04 -
Molecular formula
C26H29ClN2O4S -
PubChem identifier
5312122 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC -
Source
Synthetic
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Research areas
