GW 3965 hydrochloride, LXR agonist (ab141299)
Key features and details
- Potent and selective LXR agonist
- CAS Number: 405911-17-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GW 3965 hydrochloride, LXR agonist -
Description
Potent and selective LXR agonist -
Biological description
Potent and selective LXR agonist (EC50 values are 190 and 30 nM at hLXRα and hLXRβ, respectively). Reduces Ang II-mediated vasopressor responses in rats. Orally active. Anti-inflammatory, Hypolipidemic and antitumor agent. Active in vivo and in vitro.
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Purity
> 98% -
CAS Number
405911-17-3 -
Chemical structure
Properties
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Chemical name
3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneacetic acid hydrochloride -
Molecular weight
618.52 -
Molecular formula
C33H31ClF3NO3.HCl -
PubChem identifier
16078973 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Clc4c(cccc4CN(CCCOc1cc(CC(=O)O)ccc1)CC(c2ccccc2)c3ccccc3)C(F)(F)F -
Source
Synthetic
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Research areas
