TLCK (Tosyl-L-lysyl-chloromethane hydrochloride), Trypsin inhibitor (ab144542)
Key features and details
- Irreversible inhibitor of trypsin and trypsin-like serine proteases
- CAS Number: 4238-41-9
- Purity: > 95%
Soluble in methanol (50mg/mL), DMSO (5mM) or water. Stock solutions up to 10mM can be prepared in aqueous buffers with pH 6.0 or lower.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
TLCK (Tosyl-L-lysyl-chloromethane hydrochloride), Trypsin inhibitor -
Description
Irreversible inhibitor of trypsin and trypsin-like serine proteases -
Alternative names
- Tosyl-L-lysyl-chloromethane hydrochloride
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Biological description
Irreversible inhibitor of trypsin and trypsin-like serine proteases. Blocks LPS- or cytokine-induced NF-κB activation. Inhibits caspase processing; blocks apoptosis. Active in vitro and in vivo. -
Purity
> 95% -
General notes
This product has been reported to be very unstable in solutions with a pH above 6, at 25 oC.
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CAS Number
4238-41-9 -
Chemical structure
Properties
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Chemical name
N-[(3S)-7-Amino-1-chloro-2-oxoheptan-3-yl]-4-methylbenzenesulfonamide hydrochloride
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Molecular weight
369.30 -
Molecular formula
C14H21CIN2O3S.HCl -
PubChem identifier
73093 -
Storage instructions
Store at -20°C. Please see notes section. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in methanol (50mg/mL), DMSO (5mM) or water. Stock solutions up to 10mM can be prepared in aqueous buffers with pH 6.0 or lower.
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl.Cl -
Source
Synthetic
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Research areas