JH-II-127, LRRK2 inhibitor (ab254490)
Key features and details
- Highly potent, selective, and brain penetrant LRRK2 inhibitor
- CAS Number: 1700693-08-8
Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
JH-II-127, LRRK2 inhibitor -
Description
Highly potent, selective, and brain penetrant LRRK2 inhibitor -
Biological description
highly potent, selective, and brain penetrant LRRK2 inhibitor. (IC50 values are 2.2, 6.6 and 47.7 nM for G2019S-mutant, wild-type and A2016T-mutant LRRK2, respectively). Selective for LRRK2 over a panel of 138 kinases. Orally bioavailable.
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CAS Number
1700693-08-8 -
Chemical structure
Properties
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Chemical name
[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone
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Molecular weight
416.87 -
Molecular formula
C19H21ClN6O3 -
PubChem identifier
112499966 -
Storage instructions
Shipped at Room Temperature. Store at Room Temperature. -
Solubility overview
Soluble in DMSO to 100 mM
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CNC1=NC(=NC2=C1C(=CN2)Cl)NC3=C(C=C(C=C3)C(=O)N4CCOCC4)OC -
Source
Synthetic