ISO 1, MIF-Antagonist, MIF antagonist (ab142140)
Key features and details
- Potent, cell-permeable MIF antagonist
- CAS Number: 478336-92-4
- Purity: > 99%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ISO 1, MIF-Antagonist, MIF antagonist -
Description
Potent, cell-permeable MIF antagonist -
Biological description
Potent, cell-permeable MIF (migration inhibitory factor) antagonist (IC50 = 25 μM). Targets catalytic pocket of MIF. Inhibits TNF release from macrophages. Anti-inflammatory. Active in vitro and in vivo.
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Purity
> 99% -
CAS Number
478336-92-4 -
Chemical structure
Properties
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Chemical name
4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester -
Molecular weight
235.24 -
Molecular formula
C12H13NO4 -
PubChem identifier
6098948 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(OC)CC1CC(=NO1)c2ccc(O)cc2 -
Source
Synthetic
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Research areas