Importazole, nuclear transport receptor importin-beta inhibitor (ab146155)
Key features and details
- Selective nuclear transport receptor importin-β inhibitor
- CAS Number: 662163-81-7
- Purity: > 99%
- Soluble in ethanol to 25 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Importazole, nuclear transport receptor importin-beta inhibitor -
Description
Selective nuclear transport receptor importin-β inhibitor -
Biological description
Selective nuclear transport receptor importin-β inhibitor (IC50 = 25 μM). Blocks SINC localization at the nuclear envelope. Impairs release of importin-β cargo and induces defects in defects in spindle assembly during mitosis.
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Purity
> 99% -
CAS Number
662163-81-7 -
Chemical structure
Properties
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Chemical name
N-(1-Phenylethyl)-2-(1-pyrrolidinyl)-4-quinazolinamine
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Molecular weight
318.42 -
Molecular formula
C20H22N4 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(Nc1nc(nc2ccccc12)N3CCCC3)c4ccccc4 -
Source
Synthetic
