IEM-1460, GluR2 lacking AMPA receptor blocker (ab141507)
Key features and details
- Selective GluR2 lacking AMPA receptor blocker. Open channel blocker.
- CAS Number: 121034-89-7
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
IEM-1460, GluR2 lacking AMPA receptor blocker -
Description
Selective GluR2 lacking AMPA receptor blocker. Open channel blocker. -
Biological description
Selective, Ca2+ permeable GluR2-lacking AMPA receptor blocker (IC50 values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). Blocks NMDA receptor-mediated currents. Shows anticonvulsant effects in vivo.
Also available in simple stock solutions (ab146737) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS Number
121034-89-7 -
Chemical structure
Properties
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Chemical name
N,N,N-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminium bromide hydrobromide -
Molecular weight
454.33 -
Molecular formula
C19H37BrN2.HBr -
PubChem identifier
6604954 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C3)C2.Br.[Br-] -
Source
Synthetic
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Research areas
