A 803467, NaV1.8 channel blocker (ab120282)
Key features and details
- Selective NaV1.8 channel blocker
- CAS Number: 944261-79-4
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
A 803467, NaV1.8 channel blocker -
Description
Selective NaV1.8 channel blocker -
Biological description
Selective blocker of NaV1.8 channels (IC50 = 8 nM for human NaV1.8 ). Shows greater than 100-fold selectivity over human NaV1.2, NaV1.3, NaV1.5, and NaV1.7 (IC50 values =1 μM). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive.
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Purity
> 98% -
CAS Number
944261-79-4 -
Chemical structure
Properties
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Chemical name
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide -
Molecular weight
357.79 -
Molecular formula
C19H16ClNO4 -
PubChem identifier
16038374 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(Nc1cc(OC)cc(OC)c1)c2ccc(o2)c3ccc(Cl)cc3 -
Source
Synthetic
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Research areas
