HsAldolase ChIP probe (ab83590)
Overview
-
Product name
HsAldolase ChIP probe -
General notes
Accession number: NM_184043.The HsALDOA primers and probe can be can be used to quantify a control locus in chromatin immunoprecipitation (ChIP) assays with chromatin prepared from human cells. ALDOA (Fructose-bisphosphate aldolase A) is a moderately expressed housekeeping gene. The primers and probe are located in intron 2, within 1 kb of the transcription start site. In most cell types, this locus is enriched with histone modifications associated with active gene transcription such as Histone H3 K9 acetylation (see image with ab4441). Whereas it shows low levels of histone modifications associated with silencing such as Histone H3 K9 tri methylation (see image with ab8898).
-
Tested applications
Suitable for: Real Time PCRmore details
Properties
-
Form
Liquid -
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Store in the dark. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: ddH20 -
Concentration information loading... -
Research areas
-
Function
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein. -
Pathway
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. -
Involvement in disease
Defects in ALDOA are the cause of glycogen storage disease type 12 (GSD12) [MIM:611881]; also known as red cell aldolase deficiency. A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis. -
Sequence similarities
Belongs to the class I fructose-bisphosphate aldolase family. - Information by UniProt
-
Alternative names
- ALDA
- Aldo1
- ALDOA
see all
