HA-1077 (Fasudil) (mM/ml), ROCK2 inhibitor (ab146700)
Key features and details
- ROCK2 inhibitor. 1 ml water soluble pack.
- CAS Number: 103745-39-7
- Purity: > 98%
- Soluble in 1ml of water to give specified mM/ml concentration
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
HA-1077 (Fasudil) (mM/ml), ROCK2 inhibitor -
Description
ROCK2 inhibitor. 1 ml water soluble pack. -
Alternative names
- Fasudil
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Biological description
ROCK2 inhibitor (IC50 = 1.9 µM). Also shown to inhibit PRK2 (IC50 = 4 µM), MSK1 (IC50 = 5 µM), Rsk2 (IC50 = 15 µM), PKA, p70 S6 Kinase, CaM Kinase and MLCK. Calcium antagonist and vasodilator.
Soluble in 1 ml water to give specified mM/ml concentration. Find out more. -
Purity
> 98% -
CAS Number
103745-39-7 -
Chemical structure
Properties
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Chemical name
1-(5-Isoquinolinylsulfonyl)homopiperazine hydrochloride -
Molecular weight
327.83 -
Molecular formula
C14H17N3O2S.HCl -
PubChem identifier
163751 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1ml of water to give specified mM/ml concentration -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.O=S(=O)(c2cccc1cnccc12)N3CCCNCC3 -
Source
Synthetic
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Research areas
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription