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Cancer Drug resistance Topoisomerases

Gatifloxacin, Fluoroquinolone antibiotic (ab141184)

Key features and details

  • Fluoroquinolone antibiotic
  • CAS Number: 112811-59-3
  • Purity: > 98%
  • Soluble in DMSO to 5 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    Gatifloxacin, Fluoroquinolone antibiotic
  • Description

    Fluoroquinolone antibiotic
  • Alternative names

    • AM1155
  • Biological description

    Fluoroquinolone antibiotic. Inhibits bacterial DNA gyrase and type II topoisomerase (IC50 values are 0.109 and 13.8 µg/ml respectively. Pharmacologically active following oral administration. Crosses the blood-brain barrier.

  • Purity

    > 98%
  • CAS Number

    112811-59-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
  • Molecular weight

    375.40
  • Molecular formula

    C19H22FN3O4
  • PubChem identifier

    5379
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CN(CCN1)c2c(F)cc3c(c2OC)N(C=C(C3=O)C(=O)O)C4CC4
  • Source

    Synthetic

  • Research areas

    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Synthesis
    • Topoisomerases
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Domain Families
    • Zinc Finger
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • Nuclear Hormone Receptors
    • Estrogen
    • Neuroscience
    • Endocrine system
    • Gonadotrophic axis
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Estrogen
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • Nuclear Hormone Receptors
    • Vitamin D Receptor
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Vitamin D Receptor
    • Cancer
    • Signal transduction
    • Nuclear signaling
    • Nuclear hormone receptors
    • Estrogen
    • Cancer
    • Signal transduction
    • Nuclear signaling
    • Nuclear hormone receptors
    • Other
    • Cancer
    • Tumor biomarkers
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    • Antibiotic
    • Biochemicals
    • Chemical Type
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    • Biochemicals
    • Chemical Type
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    • General
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    • Research Area
    • Cancer
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    • General
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    • Research Area
    • Cancer
    • DNA, RNA & protein synthesis
    • Topoisomerase
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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