Exemestane, Steroidal aromatase (CYP19) inhibitor (ab141084)
Key features and details
- Irreversible, orally active, steroidal aromatase (CYP19) inhibitor
- CAS Number: 107868-30-4
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Exemestane, Steroidal aromatase (CYP19) inhibitor -
Description
Irreversible, orally active, steroidal aromatase (CYP19) inhibitor -
Biological description
Irreversible, orally active, steroidal aromatase (CYP19) inhibitor (Ki = 26 nM). Anticancer activity in vitro and in vivo, effective against breast cancer.
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Purity
> 99% -
CAS Number
107868-30-4 -
Chemical structure
Properties
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Chemical name
6-Methyleneandrosta-1,4-diene-3,17-dione -
Molecular weight
296.41 -
Molecular formula
C20H24O2 -
PubChem identifier
60198 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C3C=C4C(=C)C[C@@H]1[C@H](CC[C@]2(C)C(=O)CC[C@@H]12)[C@@]4(C)C=C3 -
Source
Synthetic
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Research areas
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
