alpha-MSH (free acid), Endogenous melanocortin receptor agonist (ab120205)
Key features and details
- Endogenous melanocortin receptor agonist
- CAS Number: 10466-28-1
- Purity: > 95%
- Soluble in water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
alpha-MSH (free acid), Endogenous melanocortin receptor agonist -
Description
Endogenous melanocortin receptor agonist -
Biological description
Free acid form of the endogenous melanocortin receptor agonist involved in feeding, homeostasis, body weight and inflammation.
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Purity
> 95% -
CAS Number
10466-28-1 -
Chemical structure
Properties
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Molecular weight
1665.87 -
Molecular formula
C77H108N20O20S -
Sequence
SYSMEHFRWGKPV (Modifications: N-terminal acetyl) -
PubChem identifier
16131203 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
- Biochemicals
- Pharmacology
- Receptors & Transporters
- Peptide Receptors
- Melanocyte Stimulating Hormone
- Agonists
- Biochemicals
- Research Area
- Pain & inflammation
- Peptide Receptors
- Melanocyte Stimulating Hormone
- Agonists
Images
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Functional Studies - alpha-MSH (free acid), Endogenous melanocortin receptor agonist (ab120205)ab24851 staining cAMP in MALME-3M cells treated with α-MSH (ab120205), by ICC/IF. Increase of cAMP correlates with increased concentration of α-MSH, as described in literature.
The cells were incubated at 37°C for 2h in media containing different concentrations of ab120205 (α-MSH) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab24851 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.