FR 139317, ETA receptor antagonist (ab144636)
Key features and details
- Highly selective, potent, competitive ETA receptor antagonist
- CAS Number: 142375-60-8
- Purity: > 98%
- Soluble in ethanol to 100 mM, in DMSO to 100 mM and in 1eq. HCl to 100 mM.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
FR 139317, ETA receptor antagonist -
Description
Highly selective, potent, competitive ETA receptor antagonist -
Biological description
Highly selective, potent, competitive ETA receptor antagonist (Ki values are 1 nM and 7.3 μM for ETA and ETB, respectively). Inhibits endothelin-1-induced vasoconstriction in vivo.
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Purity
> 98% -
CAS Number
142375-60-8 -
Chemical structure
Properties
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Chemical name
N-[(Hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl-1-methyl-D-tryptophyl-3-(2-pyridinyl)-D-alanine -
Molecular weight
604.75 -
Molecular formula
C33H44N6O5 -
PubChem identifier
107810 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM, in DMSO to 100 mM and in 1eq. HCl to 100 mM. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(N[C@@H](CC(C)C)C(=O)N[C@H](Cc2cn(C)c1ccccc12)C(=O)N[C@H](Cc3ccccn3)C(=O)O)N4CCCCCC4 -
Source
Synthetic
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Research areas
