Fostriecin, PP2A and PP4 inhibitor (ab144255)
Key features and details
- Potent PP2A and PP4 inhibitor
- CAS Number: 87860-39-7
- Purity: > 98%
- Soluble in water to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Streptomyces pulveraceous
Overview
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Product name
Fostriecin, PP2A and PP4 inhibitor -
Description
Potent PP2A and PP4 inhibitor -
Biological description
Potent PP2A and PP4 inhibitor (IC50 values are 3.2 and 3 nM, respectively). Inhibits topoisomerase II (IC50 = 40 μM). Weakly inhibits PP1 (IC50 = 131 μM). Induces cell cycle arrest at G2-M-phase. Shows anti-ischemic, antitumor and antibiotic effects in vivo. Centrally active. -
Purity
> 98% -
CAS Number
87860-39-7 -
Chemical structure
Properties
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Chemical name
[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-Trihydroxy-3-methyl-1-[(2R)-6-oxo-2,3-dihydropyran-2-yl]trideca-1,7,9,11-tetraen-4-yl] hydrogen phosphate sodium -
Molecular weight
452.37 -
Molecular formula
C19H26NaO9P -
PubChem identifier
16759606 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@](/C=C/[C@H]1CC=CC(=O)O1)([C@@H](C[C@H](/C=C\C=C/C=C/CO)O)OP(=O)(O)[O-])O.[Na+] -
Source
Streptomyces pulveraceous
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Research areas
