Ezetimibe, cholesterol absorption inhibitor (ab254455)
Key features and details
- Potent selective cholesterol absorption inhibitor
- CAS Number: 163222-33-1
- Purity: > 98%
Soluble in DMSO to 50 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ezetimibe, cholesterol absorption inhibitor -
Description
Potent selective cholesterol absorption inhibitor -
Alternative names
- Ezetrol
- SCH-58235
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Biological description
Potent selective cholesterol absorption inhibitor. Inhibits cholesterol absorption in the intestine by preventing uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter. Ezetimibe reduces plasma cholesterol levels from 964 to 374 mg/dL, from 726 to 231 mg/dL, and from 516 to 178 mg/dL in the western, low-fat, and cholesterol-free diet mice, respectively.
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Purity
> 98% -
General notes
Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
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CAS Number
163222-33-1 -
Chemical structure
Properties
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Chemical name
(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
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Molecular weight
409.43 -
Molecular formula
C24H21F2NO3 -
PubChem identifier
150311 -
Storage instructions
Shipped at Room Temperature. Store at Room Temperature. Please see notes section. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 50 mM and in ethanol to 25 mM
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Handling
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O -
Source
Synthetic
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Research areas
