LRRK2-IN-1, LRRK2 inhibitor (ab254524)
Key features and details
- Potent and selective inhibitor of the Parkinson’s disease kinase LRRK2
- CAS Number: 1234480-84-2
Soluble in DMSO and ethanol up to 100mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
LRRK2-IN-1, LRRK2 inhibitor -
Description
Potent and selective inhibitor of the Parkinson’s disease kinase LRRK2 -
Alternative names
- LRRK2IN1
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Biological description
Potent and selective inhibitor of the Parkinson’s disease kinase LRRK2. Benzodiazepine based derivative. Inhibits both G2019S mutant and wild-type LRRK2 kinase activity (IC50 values are 6 and 13 nM respectively). Causes dephosphorylation, ubiquitination and degradation of LRRK2. Inhibits IFN-γ-induced monocyte maturation in vitro.
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CAS Number
1234480-84-2 -
Chemical structure
Properties
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Chemical name
2-[2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one
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Molecular weight
570.69 -
Molecular formula
C31H38N8O3 -
PubChem identifier
46843906 -
Storage instructions
Shipped at Room Temperature. Store at +4°C. -
Solubility overview
Soluble in DMSO and ethanol up to 100mM
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Handling
Refer to SDS for further information.
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SMILES
CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC -
Source
Synthetic
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Research areas
