EHop-016, Rac GTPase inhibitor (ab229171)
Key features and details
- Specific Rac GTPase inhibitor
- CAS Number: 1380432-32-5
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
EHop-016, Rac GTPase inhibitor -
Description
Specific Rac GTPase inhibitor -
Biological description
Specific Rac GTPase inhibitor. Analog of NSC-23766 (ab142161). Approximately 100-fold more potent against Rac (IC50 = 1.1 μM) than NSC-23766. Specific for Rac1 and Rac3 at concentrations of ≤5 μM. At higher concentrations (10μM) inhibits the the related Rho GTPase Cdc42. Also inhibits the activity of the Rac downstream effector p21-activated kinase (PAK), lamellipodia extension, and cell migration in metastatic cancer cells.
-
Purity
> 98% -
CAS Number
1380432-32-5
Properties
-
Chemical name
N4-(9-Ethylcarbazol-3-yl)-2-N2-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine -
Molecular weight
430.55 -
Molecular formula
C25H30N6O -
PubChem identifier
51031035 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CCN1C2=C(C=C(C=C2)NC3=NC(=NC=C3)NCCCN4CCOCC4)C5=CC=CC=C51 -
Source
Synthetic
-
Research areas