Echinomycin, HIF-1alpha inhibitor (ab144247)
Key features and details
- Potent, reversible cell-permeable HIF-1α inhibitor
- CAS Number: 512-64-1
- Purity: > 98%
- Soluble in DMSO to 5 mM
- Form / State: Solid
- Source: Streptomyces echinatus
Overview
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Product name
Echinomycin, HIF-1alpha inhibitor -
Description
Potent, reversible cell-permeable HIF-1α inhibitor -
Biological description
Potent, reversible cell-permeable HIF-1α inhibitor (EC50 = 1.2 nM, hypoxia-induced HIF-1 transcription activity in U215 cells). Specifically intercalates into DNA. Antibacterial, antiviral, antiangiogenic and antitumor effects in vivo. -
Purity
> 98% -
CAS Number
512-64-1 -
Chemical structure
Properties
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Chemical name
N-[2,4,12,15,17,25-Hexamethyl-29-methylsulfanyl-3,6,10,13,16,19,23,26-octaoxo-11,24-di(propan-2-yl)-7-(quinoxaline-2-carbonylamino)-9,22-dioxa-28-thia-2,5,12,15,18,25-hexazabicyclo[12.12.3]nonacosan-20-yl]quinoxaline-2-carboxamide -
Molecular weight
1101.26 -
Molecular formula
C51H64N12O12S2 -
PubChem identifier
3197 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1C(=O)N(C2CSC(C(C(=O)N(C(C(=O)OCC(C(=O)N1)NC(=O)C3=NC4=CC=CC=C4N=C3)C(C)C)C)N(C(=O)C(NC(=O)C(COC(=O)C(N(C2=O)C)C(C)C)NC(=O)C5=NC6=CC=CC=C6N=C5)C)C)SC)C -
Source
Streptomyces echinatus
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Research areas
