Compound 55, DOT1L Inhibitor, DOT1L inhibitor (ab145525)
Key features and details
- Highly potent, selective DOT1L inhibitor
- CAS Number: 1381761-52-9
- Purity: > 98%
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Compound 55, DOT1L Inhibitor, DOT1L inhibitor -
Description
Highly potent, selective DOT1L inhibitor -
Biological description
Highly potent, selective DOT1L inhibitor (Ki = 0.46 nM). Shows antiproliferative effects (EC50 values are 4.4, 8.1 and 10 μM for MV4-11, THP1 and NB4 leukemia cells, respectively). Binds to the DOT1L:nucleosome complex (Kd = 66 nM). Competes with SAM/SAH, but not the substrate nucleosome, on binding to DOT1L.
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Purity
> 98% -
CAS Number
1381761-52-9 -
Chemical structure
Properties
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Chemical name
5'-Deoxy-5'-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]adenosine hydrochloride -
Molecular weight
577.13 -
Molecular formula
C27H40N8O4.HCl -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.CC(C)(C)c1ccc(cc1)NC(=O)NCCCN(C[C@H]4O[C@@H](n3cnc2c(N)ncnc23)C(O)[C@H]4O)C(C)C -
Source
Synthetic
