Canertinib (CI-1033), EGFR and HER2/ErbB2 tyrosine kinase inhibitor (ab141402)
Key features and details
- Potent irreversible EGFR and HER2/ErbB2 tyrosine kinase inhibitor
- CAS Number: 289499-45-2
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Canertinib (CI-1033), EGFR and HER2/ErbB2 tyrosine kinase inhibitor -
Description
Potent irreversible EGFR and HER2/ErbB2 tyrosine kinase inhibitor -
Alternative names
- CI-1033
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Biological description
Potent, irreversible pan-ErbB tyrosine kinase inhibitor (IC50 values are 1.5 and 9 nM at EGFR and ErbB2 respectively). Orally active. Antitumor and radiation-sensitizing agent. Active in vivo and in vitro. -
Purity
> 99% -
CAS Number
289499-45-2 -
Chemical structure
Properties
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Chemical name
N-[4-(3-Chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride -
Molecular weight
558.86 -
Molecular formula
C24H25ClFN5O3.2HCl -
PubChem identifier
156413 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl -
Source
Synthetic
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Research areas
