C 646, p300/CBP Inhibitor, p300/CBP HAT inhibitor (ab142163)
Key features and details
- Cell-permeable, competitive, selective, potent p300/CBP HAT inhibitor
- CAS Number: 328968-36-1
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
C 646, p300/CBP Inhibitor, p300/CBP HAT inhibitor -
Description
Cell-permeable, competitive, selective, potent p300/CBP HAT inhibitor -
Biological description
Cell-permeable, competitive, selective, potent p300/CBP histone acetyltransferase inhibitor (Ki = 400 nM). Blocks dynamic acetylation. Anticancer agent. Active in vitro and in vivo. -
Purity
> 98% -
CAS Number
328968-36-1 -
Chemical structure
Properties
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Chemical name
4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid -
Molecular weight
445.43 -
Molecular formula
C24H19N3O6 -
PubChem identifier
2871948 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C=C(C(=C1)C2=CC=C(O2)C=C3C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C -
Source
Synthetic
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Research areas
