Daminozide, histone demethylase KDM2/7 subfamily inhibitor (ab144621)
Key features and details
- Selective histone demethylase KDM2/7 subfamily inhibitor
- CAS Number: 1596-84-5
- Purity: > 98%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Daminozide, histone demethylase KDM2/7 subfamily inhibitor -
Description
Selective histone demethylase KDM2/7 subfamily inhibitor -
Alternative names
- Succinic acid mono(2,2-dimethylhydrazide)
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Biological description
Selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases (KDM3, KDM4, KDM5, KDM6) and 2-oxoglurate oxygenases (FIH, PHD2, BBOX1) (IC50 values >100 μM). Active in vitro. Cell-permeable.
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Purity
> 98% -
CAS Number
1596-84-5 -
Chemical structure
Properties
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Chemical name
1-(2,2-Dimethylhydrazide)butanedioic acid -
Molecular weight
160.17 -
Molecular formula
C6H12N2O3 -
PubChem identifier
15331 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)NC(=O)CCC(=O)O -
Source
Synthetic
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Research areas
