BRL 54443, agonist at 5-HT1E and 5-HT1F receptors (ab120627)
Key features and details
- Selective agonist at 5-HT1E and 5-HT1F receptors
- CAS Number: 57477-39-1
- Purity: > 99%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BRL 54443, agonist at 5-HT1E and 5-HT1F receptors -
Description
Selective agonist at 5-HT1E and 5-HT1F receptors -
Biological description
Potent, high affinity and selective agonist at 5-HT1E/1F receptors (pKi values are 8.7 and 8.9, respectively). Displays >30-fold selectivity for human 5-HT over dopamine receptors (pKi values are 7.2 (5-HT1A), 6.9 (5-HT1B), 7.2 (5-HT1D), 5.9 (5-HT2A), 7.0 (5-HT2B), 6.5 (5-HT2C), 6.3 (D2) and 6.2 (D3)).
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Purity
> 99% -
CAS Number
57477-39-1 -
Chemical structure
Properties
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Chemical name
5-Hydroxy-3-(1-methylpiperidin-4-yl)-1H-indole -
Molecular weight
230.31 -
Molecular formula
C14H18N2O -
PubChem identifier
2438 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCC(CC1)c2cnc3ccc(O)cc23 -
Source
Synthetic
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Research areas
