Biotin-VAD-FMK, pan-caspase inhibitor (ab142032)
Key features and details
- Pan-caspase inhibitor
- CAS Number:
- Purity: > 95%
- Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Biotin-VAD-FMK, pan-caspase inhibitor -
Description
Pan-caspase inhibitor -
Biological description
Irreversible, pancaspase inhibitor. Inhibits TNFα-mediated apoptosis in vitro (IC50 = 0.7 μM). Immunosuppressive, inhibits T cell proliferation. Active in vivo and in vitro. Cell-permeable. -
Purity
> 95% -
Chemical structure
Properties
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Molecular weight
672.81 -
Molecular formula
C30H49FN6O8S -
Sequence
VAD (Modifications: N-terminal biotinyl; C-terminal FMK; Asp-3 = Asp(OMe)) -
PubChem identifier
44135213 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Supplied in DMSO (10 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)CCCCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2 -
Source
Synthetic
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Research areas
