Anti-STUB1/CHIP antibody
See all STUB1/CHIP primary antibodies

Rabbit polyclonal to STUB1/CHIP

Rabbit

Detects human carboxyl terminus of hsc70-interacting protein (CHIP).Detects a band of approximately 35 kDa representing CHIP from COS-1 cells overexpressing the human gene including a non-specific band at 80kDa . A customer reported that in mouse cerebrum the antibody detects a band of 35kDa as well as two small mon-specific at 44 and 70 kDa.

Synthetic peptide corresponding to Human STUB1/CHIP aa 218-232.
Sequence:

VDEKRKKRDIPDYLC

(Peptide available as ab4934)

Run BLAST with Run BLAST with

Liquid

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS

Immunogen affinity purified

A recently identified protein, termed carboxyl terminus of hsc70-interacting protein (CHIP), has been shown to interact both with the constitutive form of hsc70 and the stress inducible form, hsp70. This novel 35 kDa cytoplasmic protein has been shown to be highly expressed in striated muscle in vivo. Additional studies have shown that this protein is expressed over a broad range of cultured tissues. Through immunoprecipitation experiments, CHIP has been shown to directly bind to the carboxyl terminus of hsc70 and hsp70 where it decreases ATPase activity and reduces overall chaperone efficiency. CHIP has also been identified as an important protein in the ubiquitin-proteasome system. CHIP contains a U-box domain and acts as an E3 ubiquitin-ligase in conjunction with hsc70 and hsp90.

Polyclonal

IgG

• Signal Transduction
• Protein Trafficking
• Chaperones
• Heat Shock Proteins

• Epigenetics and Nuclear Signaling
• Nuclear Signaling Pathways
• SMADs

• Epigenetics and Nuclear Signaling
• Cell cycle
• Ubiquitin ligases

• Epigenetics and Nuclear Signaling
• Ubiquitin & Ubiquitin Like Modifiers
• E3 Ubiquitin Ligases