Anti-CRM1 antibody
See all CRM1 primary antibodies

Rabbit polyclonal to CRM1

Rabbit

Synthetic peptide corresponding to Human CRM1 aa 1043-1058.
Sequence:

RQADEEKHKRQMSVPGS

(Peptide available as ab41768)

Run BLAST with Run BLAST with

Liquid

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS

Immunogen affinity purified

Diffusion of metabolites and small non-nuclear molecules as well as active, mediated import of protein and export of protein and RNA through the nuclear envelope occurs through nuclear pore complexes or NPC’s. NPC’s contain up to 100 different polypeptides which have a combined mass of about 125 megadaltons. The channel available for passive transport through the NPC is about 9-10 nm in diameter while carrier mediated changes in the NPC result in a ~25 nm channel used for larger, actively transported molecules. Active transport of molecules through the NPC is a signal-mediated process that is not well understood. Proteins to be exported from the nucleus to cytoplasm contain leucine-rich nuclear export signals (NESs). NESs are recognized by transport receptors belonging to the importin-beta family of proteins. It has been shown that NES export is mediated by CRM 1 (Chromosome Region Maintenance 1), an importin-beta family member that binds NESs, Ran:GTP, and Ran binding protein (RanBP). CRM 1 mediates the nuclear exportation of numerous proteins, including histone deacetylases (HDACs), viral proteins, immunophilins, and STAT 1.

Polyclonal

IgG

• Signal Transduction
• Protein Trafficking
• Nuclear Import / Export

• Epigenetics and Nuclear Signaling
• DNA / RNA
• RNA Processing
• Other

• Epigenetics and Nuclear Signaling
• Nuclear Signaling Pathways
• Nuclear Receptors
• Nuclear Pore Complex