Anti-CD20 antibody (ab206936)
Key features and details
- Human monoclonal to CD20
- Suitable for: Neutralising
- Isotype: IgG1
Overview
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Product name
Anti-CD20 antibody
See all CD20 primary antibodies -
Description
Human monoclonal to CD20 -
Host species
Human -
Tested applications
Suitable for: Neutralisingmore details -
Immunogen
Fusion protein corresponding to Human CD20. Features the constant region of the Human IgG1 isotype and the variable region of CD20, expressed in a 293 freestyle cell expression system (HEK293).
Database link: P11836 -
Epitope
ab206936 binds to Human CD20 extracellular region amino acids 142- 184, where it acts as an agonist of the CD20 protein. -
Positive control
- WIL2-S cells
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Constituents: PBS, 0.8% Sodium chloride, 0.02% Potassium chloride, 20% Glycerol (glycerin, glycerine)
Endotoxin Level:
Concentration information loading...Purity
Protein A purifiedClonality
MonoclonalIsotype
IgG1Light chain type
kappaResearch areas
Associated products
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Isotype control
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Related Products
Applications
Our Abpromise guarantee covers the use of ab206936 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application Abreviews Notes Neutralising Use at an assay dependent concentration. EC50: 0.24 μg/ml
Target
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Function
This protein may be involved in the regulation of B-cell activation and proliferation. -
Tissue specificity
Expressed on B-cells. -
Involvement in disease
Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. -
Sequence similarities
Belongs to the MS4A family. -
Post-translational
modificationsPhosphorylated. Might be functionally regulated by protein kinase(s). -
Cellular localization
Membrane. - Information by UniProt
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Alternative names
- APY antibody
- ATOPY antibody
- B lymphocyte antigen CD20 antibody
see all
Images
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Neutralising - Anti-CD20 antibody (ab206936)
WIL2-S cells treated with various concentrations of ab206936 + 10% rabbit complement. EC50 = 0.24 µg/mL.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab206936 has not yet been referenced specifically in any publications.
Images
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Neutralising - Anti-CD20 antibody (ab206936)
WIL2-S cells treated with various concentrations of ab206936 + 10% rabbit complement. EC50 = 0.24 µg/mL.
