Angiotensin II Type 1 Receptor peptide (ab176148)
Key features and details
- Suitable for: Blocking
-
Product name
Angiotensin II Type 1 Receptor peptide
See all Angiotensin II Type 1 Receptor proteins and peptides -
Animal free
No -
Nature
Synthetic
Preparation and Storage
-
Alternative names
- AG2S
- Agtr 1
- Agtr1
see all -
Function
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. -
Tissue specificity
Liver, lung, adrenal and adrenocortical adenomas. -
Involvement in disease
Defects in AGTR1 are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Post-translational
modificationsC-terminal Ser or Thr residues may be phosphorylated. -
Cellular localization
Cell membrane. - Information by UniProt
