Aeroplysinin (Aeroplysinin-1), antiangiogenic agent (ab142685)
Key features and details
- Potent antiangiogenic agent
- CAS Number: 28656-91-9
- Purity: > 95%
- Soluble in ethanol to 25 mM and in DMSO to 25 mM
- Source: Aplysina aerophoba
Overview
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Product name
Aeroplysinin (Aeroplysinin-1), antiangiogenic agent -
Description
Potent antiangiogenic agent -
Alternative names
- Aeroplysinin-1
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Biological description
Potent antiangiogenic agent. Inhibits COX-2 expression. Selectivity for endothelial cells. Able to induce apoptosis via capsase activation, chromatin condensation and nuclear fragmentation. Antibiotic and cytotoxic effects (IC50 = 3 μm) and displays a wide-spectrum antitumor activity. Active in vivo.
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Purity
> 95% -
CAS Number
28656-91-9 -
Chemical structure

Properties
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Chemical name
2-[(1S,6R)-3,5-Dibromo-1,6-dihydroxy-4-methoxycyclohexa-2,4-dien-1-yl]acetonitrile
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Molecular weight
338.98 -
Molecular formula
C9H9Br2NO3 -
PubChem identifier
100308 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM and in DMSO to 25 mM -
Handling
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C(C(C=C1Br)(CC#N)O)O)Br -
Source
Aplysina aerophoba
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Research areas