Mexiletine hydrochloride, Sodium channel blocker (ab141823)
Key features and details
- Sodium channel blocker
- CAS Number: 5370-01-4
- Purity: > 98%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Mexiletine hydrochloride, Sodium channel blocker -
Description
Sodium channel blocker -
Biological description
Sodium channel blocker. Class IB anti-arrhythmic agent. Decreases action potential duration by shortening the repolarization phase. -
Purity
> 98% -
CAS Number
5370-01-4 -
Chemical structure
Properties
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Chemical name
1-(2,6-Dimethylphenoxy)propan-2-amine hydrochloride -
Molecular weight
215.70 -
Molecular formula
C11H17NO.HCl -
PubChem identifier
21467 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C(=CC=C1)C)OCC(C)N.Cl -
Source
Synthetic
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Research areas
Images
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Functional Studies - Mexiletine hydrochloride, Sodium channel blocker (ab141823)Mexiletine hydrochloride inhibits NaV1.4 channels heterologously expressed in Xenopus oocytes.
A. Time course of Nav1.4 current amplitude changes as a result of 1 mM Mexiletine hydrochloride (ab141823) application (marked by the horizontal bar), for each of the two test pulses. B. Currents were elicited by a double test pulse protocol applied every 10 sec, which is schematically described on the top panel. For the first pulse the holding potential is -120 mV while the second pulse is preceded by 300 ms at 60 mV. On the bottom; superimposed example current responses to the voltage stimulation, before (black) and during application of 1 mM Mexiletine hydrochloride (green).
