JX-401, p38alpha inhibitor (ab144577)
Key features and details
- Potent, cell-permeable, reversible p38α inhibitor
- CAS Number: 349087-34-9
- Purity: > 98%
- Soluble in DMSO to 75 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
JX-401, p38alpha inhibitor -
Description
Potent, cell-permeable, reversible p38α inhibitor -
Biological description
Potent, cell-permeable, reversible p38α inhibitor (IC50 = 32 nM). No activity for p38γ isoform. Anti-inflammatory agent. Active in vitro. -
Purity
> 98% -
CAS Number
349087-34-9 -
Chemical structure
Properties
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Chemical name
1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine -
Molecular weight
355.49 -
Molecular formula
C21H25NO2S -
PubChem identifier
1126109 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 75 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C=CC(=C1)SC)C(=O)N2CCC(CC2)CC3=CC=CC=C3 -
Source
Synthetic
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Research areas
