Actinomycin D (Dactinomycin), Nucleic acid and protein synthesis inhibitor (ab141058)
Key features and details
- Nucleic acid and protein synthesis inhibitor
- CAS Number: 50-76-0
- Purity: > 98%
Soluble in acetonitrilie or acetone at 10 mg/mL and in DMSO at a minimum of 1 mg/mL.
- Form / State: Solid
- Source: Streptomyces sp.
Overview
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Product name
Actinomycin D (Dactinomycin), Nucleic acid and protein synthesis inhibitor -
Description
Nucleic acid and protein synthesis inhibitor -
Alternative names
- Dactinomycin
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Biological description
Nucleic acid and protein synthesis inhibitor. Intercalates DNA, stabilizes topoisomerases I and II and inhibits transcription. Antibacterial and antitumor agent. Active in vivo and in vitro.
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Purity
> 98% -
General notes
This product is hygroscopic. Unused dilute solutions of Actinomycin D are extremely sensitive to light and tend to adsorb to plastic and glass and should be discarded. However, frozen aliquots of concentrated stock solution are stable for at least a month.
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CAS Number
50-76-0 -
Chemical structure
Properties
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Chemical name
2-Amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
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Molecular weight
1255.43 -
Molecular formula
C62H86N12O16 -
PubChem identifier
2019 -
Storage instructions
Shipped at 4°C. Store at +4°C. It is important to note that this product is reported to be light sensitive. Please see notes section. Store In the Dark. -
Solubility overview
Soluble in acetonitrilie or acetone at 10 mg/mL and in DMSO at a minimum of 1 mg/mL.
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Handling
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C -
Source
Streptomyces sp.
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Research areas
