ABT-199 (Venetoclax), Bcl-2 inhibitor. (ab217298)
Key features and details
- Potent, selective Bcl-2 inhibitor.
- CAS Number: 1257044-40-8
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ABT-199 (Venetoclax), Bcl-2 inhibitor. -
Description
Potent, selective Bcl-2 inhibitor. -
Alternative names
- 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
- GDC-0199
- Venetoclax
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Biological description
Potent, selective Bcl-2 inhibitor (Ki
-
Purity
> 98% -
CAS Number
1257044-40-8 -
Chemical structure
Properties
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Selectivity
Bcl-2
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Chemical name
2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4’-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide -
Molecular weight
868.44 -
Molecular formula
C45H50ClN7O7S -
PubChem identifier
49846579 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 50 mM -
SMILES
CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C -
Source
Synthetic
-
Research areas
