20(S)-Hydroxycholesterol, Smoothened activator (ab146146)
Key features and details
- Smoothened activator
- CAS Number: 516-72-3
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
20(S)-Hydroxycholesterol, Smoothened activator -
Description
Smoothened activator -
Alternative names
- 20(S)-OHC
- oxysterol
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Biological description
Allosteric activator of the Hedgehog (Hh) signaling pathway Smoothened (Smo) oncoprotein. Binds at a site distinct from the canonical cyclopamine binding site. Activates Hh signaling (EC50 = ~ 3 μM for induction of Hh reporter gene transcription in NIH 3T3 cells). Also exhibits osteogenic activity and activates the liver X receptor (LXR).
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CAS Number
516-72-3 -
Chemical structure
Properties
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Molecular weight
402.65 -
Molecular formula
C27H46O2 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)CCC[C@@](C)(O)[C@H]4CC[C@@H]3[C@]4(C)CC[C@H]2[C@H]3CC=C1C[C@@H](O)CC[C@@]12C -
Source
Synthetic
