2-Hydroxyflutamide, androgen receptor antagonist (ab143636)
Key features and details
- Potent androgen receptor antagonist
- CAS Number: 52806-53-8
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
2-Hydroxyflutamide, androgen receptor antagonist -
Description
Potent androgen receptor antagonist -
Biological description
Potent androgen receptor antagonist (IC50 = 15 nM). Flutamide (ab141234) metabolite. Antiproliferative agent but attenuates induction of granulosa cell apoptosis in the presence of a high T level. Active in vivo. Orally active. -
Purity
> 98% -
CAS Number
52806-53-8 -
Chemical structure
Properties
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Chemical name
2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide -
Molecular weight
292.21 -
Molecular formula
C11H11F3N2O4 -
PubChem identifier
91649 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F)O -
Source
Synthetic
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Research areas
