ZM306416 hydrochloride, VEGFR1/2 tyrosine kinase activity inhibitor (ab144576)
Key features and details
- Potent and selective VEGFR1/2 tyrosine kinase activity inhibitor
- CAS Number: 196603-47-1
- Purity: > 98%
Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ZM306416 hydrochloride, VEGFR1/2 tyrosine kinase activity inhibitor -
Description
Potent and selective VEGFR1/2 tyrosine kinase activity inhibitor -
Biological description
Potent and selective VEGFR1/2inhibitor (IC50 values are 100 nM and 2 μM for KDR and Flt respectively). Shows antiproliferative effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
196603-47-1 -
Chemical structure
Properties
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Chemical name
4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochloride
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Molecular weight
370.12 -
Molecular formula
C16H13ClFN3O2.HCl -
PubChem identifier
5329006 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC -
Source
Synthetic
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Research areas
