Anti-Nonspecific Cytotoxic Cells antibody [5C.6] (ab2778)
Key features and details
- Mouse monoclonal [5C.6] to Nonspecific Cytotoxic Cells
- Reacts with: Rat, Horse, Cow, Dog, Pig, Tilapia, Catfish
- Isotype: IgM
Overview
-
Product name
Anti-Nonspecific Cytotoxic Cells antibody [5C.6] -
Description
Mouse monoclonal [5C.6] to Nonspecific Cytotoxic Cells -
Host species
Mouse -
Species reactivity
Reacts with: Rat, Horse, Cow, Dog, Pig, Tilapia, Catfish -
Immunogen
Other Immunogen Type corresponding to Nonspecific Cytotoxic Cells. Purified NCC cells from catfish.
-
Positive control
- This antibody as been successfully used in cytotoxic inhibition studies with NCC/NK/LAK cells, panning, and ELISA procedures. In cytotoxicity assays, this antibody is used under saturating conditions to inhibit target cell conjugation.
-
General notes
U.S. Patent Numbers: 5,028,424 and 5,229,494.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituent: 0.1% BSA -
Concentration information loading... -
Purity
Purified IgM -
Primary antibody notes
Non-specific cytotoxic cells (NCCs) in teleosts and their evolutionary homologue are a subpopulation of lymphocytes with properties that distinguish them from either B- or T-cells. One such property is that NCC/natural killer (NK)/lymphokine activated killer (LAK) cells express spontaneous, non-major histocompatibility complex restricted cytotoxic activity. NCC and LAK lyse a variety of transformed murine and human B-cell, T-cell and myeloid targets. A 32 kDa membrane protein [non-specific cytotoxic cell receptor protein (NCCRP-1)] expressed by NCC and certain mammalian NK/LAK cells mediates this cytotoxicity. NCCRP-1 is evolutionarily conserved and is found in species ranging from marine and freshwater teleosts to higher mammals. -
Clonality
Monoclonal -
Clone number
5C.6 -
Isotype
IgM -
Research areas