YM-58483 (CRAC Channel Inhibitor, BTP2), CRAC channel inhibitor (ab144413)
Key features and details
- Store-operated Ca2+ entry blocker. Potent, selective CRAC channel inhibitor.
- CAS Number: 223499-30-7
- Purity: > 98%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
YM-58483 (CRAC Channel Inhibitor, BTP2), CRAC channel inhibitor -
Description
Store-operated Ca2+ entry blocker. Potent, selective CRAC channel inhibitor. -
Alternative names
- CRAC Channel Inhibitor, BTP2
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Biological description
Store-operated Ca2+ entry blocker. Potent, selective CRAC channel inhibitor. Inhibits thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM). Suppresses cytokine production. Potent T-cell antiproliferative agent (IC50 = 12.7 nM). Shows immunomodulatory and anti-inflammatory effects in vivo. Orally active.
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Purity
> 98% -
CAS Number
223499-30-7 -
Chemical structure
Properties
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Chemical name
N-[4-[3,5-Bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide -
Molecular weight
421.32 -
Molecular formula
C15H9F6N5OS -
PubChem identifier
2455 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(SN=N1)C(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F -
Source
Synthetic
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Research areas
