YC-1, guanylyl cyclase activator (ab120915)
Key features and details
- Reversible soluble guanylyl cyclase activator
- CAS Number: 170632-47-0
- Purity: > 99%
- Soluble in ethanol to 50 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
YC-1, guanylyl cyclase activator -
Description
Reversible soluble guanylyl cyclase activator -
Biological description
Reversible soluble guanylyl cyclase activator (EC50 = 18.6 μM). NO-independent. Induces a concentration dependent increase in cGMP in vitro. Reduces blood-brain barrier permeability through HIF-1 inhibiton in vivo. -
Purity
> 99% -
CAS Number
170632-47-0 -
Chemical structure
Properties
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Chemical name
5-[1-(Phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol -
Molecular weight
304.35 -
Molecular formula
C19H16N2O2 -
PubChem identifier
5712 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 50 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)O1 -
Source
Synthetic
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Research areas
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Co-activators/co-repressors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
