Tripolin B, Aurora A and B inhibitor (ab144378)
Key features and details
- ATP-competitive Aurora A and B inhibitor
- CAS Number: 372164-71-1
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Tripolin B, Aurora A and B inhibitor -
Description
ATP-competitive Aurora A and B inhibitor -
Biological description
ATP-competitive Aurora A and B inhibitor (IC50 values are 2.5 and 6 μM for Aurora A and B respectively). Tripolin A (ab144377) analog. Inhibits KDR, IGF1R, EGFR and FGFR (IC50 values are 6.5, 13, 72 and 38 μM respectively). -
Purity
> 98% -
CAS Number
372164-71-1 -
Chemical structure
Properties
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Chemical name
(3Z)-3-(1H-Imidazol-5-ylmethylidene)-1H-indol-2-one -
Molecular weight
211.22 -
Molecular formula
C12H9N3O -
PubChem identifier
5714572 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C2C(=C1)/C(=C/C3=CN=CN3)/C(=O)N2 -
Source
Synthetic
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Research areas