TMP-153, ACAT inhibitor (ab144403)
Key features and details
- Potent, non-competitive ACAT inhibitor
- CAS Number: 128831-46-9
- Purity: > 95%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
TMP-153, ACAT inhibitor -
Description
Potent, non-competitive ACAT inhibitor -
Biological description
Potent, non-competitive ACAT inhibitor (IC50 = 5-10 nM). Inhibits cholesterol esterification (IC50 values are 150 and 330 nM for L S180 and HepG2 cells respectively). Lowers plasma cholesterol levels and cholesterol absorption in vivo. Orally active. -
Purity
> 95% -
CAS Number
128831-46-9 -
Chemical structure
Properties
-
Chemical name
1-[4-(2-Chlorophenyl)-6,7-dimethylquinolin-3-yl]-3-(2,4-difluorophenyl)urea -
Molecular weight
437.87 -
Molecular formula
C24H18ClF2N3O -
PubChem identifier
125289 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC1=C(C=C2C(=C1)C(=C(C=N2)NC(=O)NC3=C(C=C(C=C3)F)F)C4=CC=CC=C4Cl)C -
Source
Synthetic
-
Research areas
