TAPI-1, TNF alpha processing inhibitor (ab142218)
Key features and details
- TNF-α processing inhibitor
- CAS Number: 171235-71-5
- Purity: > 95%
Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
TAPI-1, TNF alpha processing inhibitor -
Description
TNF-α processing inhibitor -
Alternative names
- TNF-alpha protease inhibitor I
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Biological description
Stable, selective inhibitor of TNF-α processing (IC50 = ~100 nM). Inhibits TACE (Pin vivo. Blocks release of TNF-α (IC50 = 50-100 µM), APP (IC50 = 1-8 µM), ACE (IC50 = 10 µM), IL6R (IC50 = 5-10 µM), TNFRI (IC50 = 5-10 µM), TNFRII (IC50 = 25-50 µM), and ObRa (leptin receptor), but not CSF-1 in vivo. Structural analog of TAPI-0.
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Purity
> 95% -
CAS Number
171235-71-5 -
Chemical structure
Properties
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Chemical name
N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide
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Molecular weight
499.60 -
Molecular formula
C26H37N5O5 -
PubChem identifier
9827273 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Soluble in DMSO to 10 mM
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Handling
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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SMILES
CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NCCN -
Source
Synthetic
